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Potrero Hill got its name from the Spanish word "potrero," meaning pasture or cattle grazing area, reflecting its history as grazing land for Mission Dolores.

The main commercial areas are centered along 18th Street and 20th Street. These streets feature local restaurants, cafes, small shops, and service businesses.

Transportation options in Potrero Hill include Muni bus lines 10, 19, 22, and 48. The neighborhood has a nearby Caltrain station at 22nd Street and relatively close access to Interstate 280 and Highway 101.

Architecturally, Potrero Hill is significant for its mix of housing styles. The area features Victorian and Edwardian homes from the late 19th and early 20th centuries, mid-century modern apartments and condos, as well as contemporary infill development and converted industrial lofts. Home types in the area include single-family houses, multi-unit buildings, condominiums, apartments, and some live/work spaces in converted warehouses.

Potrero Hill is considered a desirable place to live for several reasons. It often experiences sunnier and warmer weather than other parts of San Francisco due to its elevation and location. Many homes offer panoramic views of the city skyline, bay, or surrounding hills. The neighborhood has a quieter atmosphere and is less crowded compared to more central areas. Despite feeling secluded, it's still close to downtown and other popular areas. Potrero Hill also has a strong sense of community with local events and gathering spaces.